Transient ischemic attack and coronary artery disease: a two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Although observational studies have shown that patients who experienced transient ischemic attacks (TIAs) had a higher risk of coronary artery disease (CAD), the causal relationship is ambiguous.

Methods

We conducted a two-sample Mendelian randomization (MR) study to analyze the causal relationship between TIA and CAD using data from the FinnGen genome-wide association study. Analysis was performed using the inverse-variance weighted (IVW) method. The robustness of the results was evaluated using MR-Egger regression, the weighted median, MR pleiotropy residual sum, and outlier (MR-PRESSO) and multivariable MR analysis.

Results

Results from IVW random-effect model showed that TIA was associated with an increased risk of coronary artery atherosclerosis (OR 1.

SUBMITTER: Qi X 

PROVIDER: S-EPMC10475993 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature