Altered developmental trajectories of verbal learning skills in 22q11.2DS: associations with hippocampal development and psychosis.

ABSTRACT:

Background

The cognitive profile in 22q11.2 deletion syndrome (22q11.2DS) is often characterized by a discrepancy between nonverbal vs. verbal reasoning skills, in favor of the latter skills. This dissociation has also been observed in memory, with verbal learning skills described as a relative strength. Yet the development of these skills is still to be investigated. We thus aimed to explore verbal learning longitudinally. Furthermore, we explored verbal learning and its respective associations with hippocampal alterations and psychosis, which remain largely unknown despite their high prevalence in 22q11.2DS.

Methods

In total, 332 individuals (173 with 22q11.2DS) aged 5-30 years completed a verbal-paired associates task. Mixed-models regression analyses were conducte

SUBMITTER: Latreche C 

PROVIDER: S-EPMC10476015 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature