In vitro studies on the pharmacological potential, anti-tumor, antimicrobial, and acetylcholinesterase inhibitory activity of marine-derived Bacillus velezensis AG6 exopolysaccharide.

ABSTRACT: In the current study, Bacillus velezensis AG6 was isolated from sediment samples in the Red Sea, identified by traditional microbiological techniques and phylogenetic 16S rRNA sequences. Among eight isolates screened for exopolysaccharide (EPS) production, the R6 isolate was the highest producer with a significant fraction of EPS (EPSF6, 5.79 g L^-1). The EPSF6 molecule was found to have a molecular weight (Mw) of 2.7 × 10⁴ g mol^-1 and a number average (Mn) of 2.6 × 10⁴ g mol^-1 when it was analyzed using GPC. The FTIR spectrum indicated no sulfate but uronic acid (43.8%). According to HPLC, the EPSF6 fraction's monosaccharides were xylose, galactose, and galacturonic acid in a molar ratio of 2.0 : 0.5 : 2.0. DPPH, H₂O<

SUBMITTER: Alharbi MA 

PROVIDER: S-EPMC10476021 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature