A BODIPY-picolinium-cation conjugate as a blue-light-responsive caged group† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3ra03826b

ABSTRACT: Caged compounds protected with photolabile protecting groups (PPGs) are useful for controlling various biological events with high spatiotemporal resolution. Most of the commonly used PPGs are controlled by ultraviolet light irradiation, but it is desirable to have PPGs controlled by visible light irradiation in order to minimize tissue damage. Here, we describe a boron-dipyrromethene (BODIPY)-picolinium conjugate (BPc group) that functions as a blue-light-controllable PPG. ESR experiments indicate that the photolysis mechanism is based on intramolecular photoinduced electron transfer. We illustrate the applicability of the BPc group to biologically active compounds by employing it firstly to photocontrol release of histamine, and secondly to photocontrol release of a soluble guanylyl cycl

SUBMITTER: Ieda N 

PROVIDER: S-EPMC10476028 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature