Stressful life events increase the risk of major depressive episodes: A population-based twin study.

ABSTRACT:

Background

Previous studies have found that stressful life events (SLEs) are associated with an increased risk of adult depression. However, many studies are observational in nature and limited by methodological issues, such as potential confounding by genetic factors. Genetically informative research, such as the co-twin control design, can strengthen causal inference in observational studies. Discrete-time survival analysis has several benefits and multilevel survival analysis can incorporate frailty terms (random effects) to estimate the components of the biometric model. In the current study, we investigated associations between SLEs and depression risk in a population-based twin sample (N = 2299).

Methods

A co-twin control design was used to investigate the influ

SUBMITTER: Bjorndal LD 

PROVIDER: S-EPMC10476058 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature