Brain age and cognitive functioning in first-episode bipolar disorder.

ABSTRACT:

Background

There is significant heterogeneity in cognitive function in patients with bipolar I disorder (BDI); however, there is a dearth of research into biological mechanisms that might underlie cognitive heterogeneity, especially at disease onset. To this end, this study investigated the association between accelerated or delayed age-related brain structural changes and cognition in early-stage BDI.

Methods

First episode patients with BDI (n = 80) underwent cognitive assessment to yield demographically normed composite global and domain-specific scores in verbal memory, non-verbal memory, working memory, processing speed, attention, and executive functioning. Structural magnetic resonance imaging data were also collected from all participants and subjected to machi

SUBMITTER: Chakrabarty T 

PROVIDER: S-EPMC10476063 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature