Brain glucose metabolism in schizophrenia: a systematic review and meta-analysis of ¹⁸FDG-PET studies in schizophrenia.

ABSTRACT:

Background

Impaired brain metabolism may be central to schizophrenia pathophysiology, but the magnitude and consistency of metabolic dysfunction is unknown.

Methods

We searched MEDLINE, PsychINFO and EMBASE between 01/01/1980 and 13/05/2021 for studies comparing regional brain glucose metabolism using ¹⁸FDG-PET, in schizophrenia/first-episode psychosis v. controls. Effect sizes (Hedges g) were pooled using a random-effects model. Primary measures were regional absolute and relative CMRGlu in frontal, temporal, parietal and occipital lobes, basal ganglia and thalamus.

Results

Thirty-six studies (1335 subjects) were included. Frontal absolute glucose metabolism (Hedge's g = -0.74 ± 0.54, p = 0.01; I² = 67%) and me

SUBMITTER: Townsend L 

PROVIDER: S-EPMC10476075 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature