Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response.

ABSTRACT:

Background

Massive tumor-associated macrophage (TAM) infiltration is observed in many tumors, which usually display the immune-suppressive M2-like phenotype but can also be converted to an M1-like antitumor phenotype due to their high degree of plasticity. The macrophage polarization state is associated with changes in cell shape, macrophage morphology is associated with activation status. M1 macrophages appeared large and rounded, while M2 macrophages were stretched and elongated cells. Manipulating cell morphology has been shown to affect the polarization state of macrophages. The shape of the cell is largely dependent on cytoskeletal proteins, especially, microtubules. As a microtubule-targetting drug, vinblastine (VBL) has been used in chemotherapy. However, no study to date ha

SUBMITTER: Wang YN 

PROVIDER: S-EPMC10476141 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature