Mechanistic Investigation of the Nickel-Catalyzed Transfer Hydrocyanation of Alkynes.

ABSTRACT: The implementation of HCN-free transfer hydrocyanation reactions on laboratory scales has recently been achieved by using HCN donor reagents under nickel- and Lewis acid co-catalysis. More recently, malononitrile-based HCN donor reagents were shown to undergo the C(sp³)-CN bond activation by the nickel catalyst in the absence of Lewis acids. However, there is a lack of detailed mechanistic understanding of the challenging C(sp³)-CN bond cleavage step. In this work, in-depth kinetic and computational studies using alkynes as substrates were used to elucidate the overall reaction mechanism of this transfer hydrocyanation, with a particular focus on the activation of the C(sp³)-CN bond to generate the active H-Ni-CN transfer hydrocyanation catalyst. Comparisons of experimentally and computationally derived ¹³C kinetic isotope effect data support a direct oxidative addition mechanism of the nickel catalyst into the C(sp³)-CN bond facilitated by the coordination of the second nitrile group to the nickel catalyst.

SUBMITTER: Reisenbauer JC 

PROVIDER: S-EPMC10476158 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature