Large-scale across species transcriptomic analysis identifies genetic selection signatures associated with longevity in mammals.

ABSTRACT: Lifespan varies significantly among mammals, with more than 100-fold difference between the shortest and longest living species. This natural difference may uncover the evolutionary forces and molecular features that define longevity. To understand the relationship between gene expression variation and longevity, we conducted a comparative transcriptomics analysis of liver, kidney, and brain tissues of 103 mammalian species. We found that few genes exhibit common expression patterns with longevity in the three organs analyzed. However, pathways related to translation fidelity, such as nonsense-mediated decay and eukaryotic translation elongation, correlated with longevity across mammals. Analyses of selection pressure found that selection intensity related to the direction of longevity-cor

SUBMITTER: Liu W 

PROVIDER: S-EPMC10476176 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature