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Cobalt-Catalyzed Aerobic Aminocyclization of Unsaturated Amides for the Synthesis of Functionalized γ- and δ-Lactams.

ABSTRACT: We report the cobalt-catalyzed aminocyclization of unsaturated N-acyl sulfonamides in the presence of oxygen to provide γ- and δ-lactam aldehydes. Use of an optically active cobalt catalyst resulted in the formation of enantiomerically enriched γ-and δ-lactam alcohols. The γ-lactam aldehydes and alcohols obtained were elaborated into useful building blocks.

SUBMITTER: Freis M

PROVIDER: S-EPMC10476186 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Cobalt-Catalyzed Aerobic Aminocyclization of Unsaturated Amides for the Synthesis of Functionalized γ- and δ-Lactams.

Freis Manuel M Balkenhohl Moritz M Fischer David M DM Georgiev Tony T Sarott Roman C RC Carreira Erick M EM

Organic letters 20230823 34

We report the cobalt-catalyzed aminocyclization of unsaturated <i>N</i>-acyl sulfonamides in the presence of oxygen to provide γ- and δ-lactam aldehydes. Use of an optically active cobalt catalyst resulted in the formation of enantiomerically enriched γ-and δ-lactam alcohols. The γ-lactam aldehydes and alcohols obtained were elaborated into useful building blocks. ...[more]

PMID: 37610083

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