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Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation.

ABSTRACT: Herein, a straightforward synthetic approach for the construction of phenanthridin-6(5H)-one skeletons is disclosed. The developed protocol relies on palladium catalysis, providing controlled access to a range of functionalized phenanthridin-6(5H)-ones in 59-88% yields. Furthermore, plausible reaction pathways are proposed based on mechanistic experiments.

SUBMITTER: Geng X

PROVIDER: S-EPMC10476191 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Construction of Phenanthridinone Skeletons through Palladium-Catalyzed Annulation.

Geng Xin X He Heng H Shatskiy Andrey A Stepanova Elena V EV Alvey Gregory R GR Liu Jian-Quan JQ Kärkäs Markus D MD Wang Xiang-Shan XS

The Journal of organic chemistry 20230823 17

Herein, a straightforward synthetic approach for the construction of phenanthridin-6(5<i>H</i>)-one skeletons is disclosed. The developed protocol relies on palladium catalysis, providing controlled access to a range of functionalized phenanthridin-6(5<i>H</i>)-ones in 59-88% yields. Furthermore, plausible reaction pathways are proposed based on mechanistic experiments. ...[more]

PMID: 37611263

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