Exploring the prognostic significance of PKCε variants in cervical cancer.

ABSTRACT:

Background

Protein Kinase C-epsilon (PKCε) is a member of the novel subfamily of PKCs (nPKCs) that plays a role in cancer development. Studies have revealed that its elevated expression levels are associated with cervical cancer. Previously, we identified pathogenic variations in its different domains through various bioinformatics tools and molecular dynamic simulation. In the present study, the aim was to find the association of its variants rs1553369874 and rs1345511001 with cervical cancer and to determine the influence of these variants on the protein-protein interactions of PKCε, which can lead towards cancer development and poor survival rates.

Methods

The association of the variants with cervical cancer and its clinicopathological features was determined through geno

SUBMITTER: Zafar S 

PROVIDER: S-EPMC10476323 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature