MALAT1-regulated gene expression profiling in lung cancer cell lines.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and has a poor prognosis. Identifying biomarkers based on molecular mechanisms is critical for early diagnosis, timely treatment, and improved prognosis of lung cancer. MALAT1 has been reported to have overexpressed and tumor-promoting functions in NSCLC. It has been proposed as a potential biomarker for the diagnosis and prognosis of cancer. Therefore, this study was conducted to profile the changes in gene expression according to the regulation of expression of MALAT1 in NSCLC cell lines and to investigate the correlation through bioinformatic analysis of differentially expressed genes (DEGs).

Methods

MALAT1 expression levels were measured using RT-qPCR. The biological functions of MALAT1

SUBMITTER: Roh J 

PROVIDER: S-EPMC10476395 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature