Predicting the anti-inflammatory mechanism of Radix Astragali using network pharmacology and molecular docking.

ABSTRACT: According to current research, the primary active ingredients of Radix Astragali (RA), such as saponins, flavonoids, and polysaccharides, play an important role in anti-inflammatory effects. However, the exact molecular mechanism underlying the action was not elucidated to date. Our research attempted to determine the active components in RA and to investigate the interaction between the active components and targets involved in the anti-inflammation activity by network pharmacology and molecular docking. The active components and targets of RA were screened out by TCMSP. Thereafter, through the "anti-inflammation effect" and "inflammation" as the keywords, disease targets were obtained from the GeneCards database. The PPI network was constructed with Cytoscape 3.8.0 software to screen cor

SUBMITTER: Ren J 

PROVIDER: S-EPMC10476849 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature