Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET.

ABSTRACT:

Introduction

Tumor hypoxia is associated with poor treatment outcome. Hypoxic regions are more radioresistant than well-oxygenated regions, as quantified by the oxygen enhancement ratio (OER). In optimization of proton therapy, including OER in addition to the relative biological effectiveness (RBE) could therefore be used to adapt to patient-specific radioresistance governed by intrinsic radiosensitivity and hypoxia.

Methods

A combined RBE and OER weighted dose (ROWD) calculation method was implemented in a FLUKA Monte Carlo (MC) based treatment planning tool. The method is based on the linear quadratic model, with α and β parameters as a function of the OER, and therefore a function of the linear energy transfer (LET) and partial oxygen pressure (pO₂ ). Proton t

SUBMITTER: Henjum H 

PROVIDER: S-EPMC10476997 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature