Pseudomonas aeruginosa increases the susceptibility of Candida albicans to amphotericin B in dual-species biofilms.

ABSTRACT:

Background

Biofilms are the leading cause of nosocomial infections and are hard to eradicate due to their inherent antimicrobial resistance. Candida albicans is the leading cause of nosocomial fungal infections and is frequently co-isolated with the bacterium Pseudomonas aeruginosa from biofilms in the cystic fibrosis lung and severe burn wounds. The presence of C. albicans in multispecies biofilms is associated with enhanced antibacterial resistance, which is largely mediated through fungal extracellular carbohydrates sequestering the antibiotics. However, significantly less is known regarding the impact of polymicrobial biofilms on antifungal resistance.

Results

Here we show that, in dual-species biofilms, P. aeruginosa enhances the susceptibility of C. albicans to amphote

SUBMITTER: Alam F 

PROVIDER: S-EPMC10477122 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature