An artesunate pharmacometric model to explain therapeutic responses in falciparum malaria.

ABSTRACT:

Background

The artemisinins are potent and widely used antimalarial drugs that are eliminated rapidly. A simple concentration-effect pharmacometric model does not explain why dosing more frequently than once daily fails to augment parasite clearance and improve therapeutic responses in vivo. Artemisinins can induce a temporary non-replicative or 'dormant' drug refractory state in Plasmodium falciparum malaria parasites which may explain recrudescences observed in clinical trials despite full drug susceptibility, but whether it explains the dosing-response relationship is uncertain.

Objectives

To propose a revised model of antimalarial pharmacodynamics that incorporates reversible asexual parasite injury and temporary drug refractoriness in order to explain the failure of fre

SUBMITTER: Saralamba S 

PROVIDER: S-EPMC10477127 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature