Role of dexmedetomidine in modifying immune paralysis in patients with septic shock: randomized controlled trial.

ABSTRACT:

Background

Immune paralysis can be defined as a hypoinflammatory state associated with the incapacity of the immune system to release proinflammatory mediators despite the clearance of pathogens by antimicrobials. Persistent immune paralysis leads to failure to eradicate primary infections with a substantial increase in the risk of multiorgan dysfunction and mortality. The state of immune paralysis is caused mainly by the diminished ability of monocytes to release proinflammatory cytokines in response to endotoxin. This phenomenon is known as endotoxin tolerance. This study aimed to assess the role of dexmedetomidine in modifying immune paralysis in septic shock patients.

Methods

Twenty-four patients with septic shock were randomized into two groups of 12 patients. A continu

SUBMITTER: Elayashy M 

PROVIDER: S-EPMC10477149 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature