Dataset Information

First clinical experience with fractionated intracavitary radioimmunotherapy using [¹⁷⁷Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study.

ABSTRACT:

Background

Following resection and standard adjuvant radio- and chemotherapy, approved maintenance therapies for glioblastoma are lacking. Intracavitary radioimmunotherapy (iRIT) with ¹⁷⁷Lu-labeled 6A10-Fab fragments targeting tumor-associated carbonic anhydrase XII and injected into the resection cavity offers a novel and promising strategy for improved tumor control.

Methods

Three glioblastoma patients underwent tumor resection followed by standard radio- and chemotherapy. These patients with stable disease following completion of standard therapy underwent iRIT on compassionate grounds. After surgical implantation of a subcutaneous injection reservoir with a catheter into the resection cavity, a leakage test with [^99mTc]Tc-DTPA was performed to rule out leakage into other cerebral compartments. IRIT comprised three consecutive applications over three months for each patient, with 25%, 50%, 25% of the total activity injected. A dosimetry protocol was included with blood sampling and SPECT/CT of the abdomen to calculate doses for the bone marrow and kidneys as potential organs at risk.

Results

All three patients presented without relevant leakage after application of [^99mTc]Tc-DTPA. Two patients underwent three full cycles of iRIT (592 MBq and 1228 MBq total activity). One patient showed histologically proven tumor progression after the second cycle (526 MBq total activity). No relevant therapy-associated toxicities or adverse events were observed. Dosimetry did not reveal absorbed doses above upper dose limits for organs at risk.

Conclusions

In first individual cases, iRIT with [¹⁷⁷Lu]Lu-6A10-Fab appears to be feasible and safe, without therapy-related side effects. A confirmatory multicenter phase-I-trial was recently opened and is currently recruiting.

SUBMITTER: Roll W

PROVIDER: S-EPMC10477153 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Publications

First clinical experience with fractionated intracavitary radioimmunotherapy using [<sup>177</sup>Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study.

Roll Wolfgang W Müther Michael M Böning Guido G Delker Astrid A Warneke Nils N Gildehaus Franz-Josef FJ Schäfers Michael M Stummer Walter W Zeidler Reinhard R Reulen Hans-Jürgen HJ Stegger Lars L

EJNMMI research 20230904 1

<h4>Background</h4>Following resection and standard adjuvant radio- and chemotherapy, approved maintenance therapies for glioblastoma are lacking. Intracavitary radioimmunotherapy (iRIT) with <sup>177</sup>Lu-labeled 6A10-Fab fragments targeting tumor-associated carbonic anhydrase XII and injected into the resection cavity offers a novel and promising strategy for improved tumor control.<h4>Methods</h4>Three glioblastoma patients underwent tumor resection followed by standard radio- and chemothe ...[more]

PMID: 37665396

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Dataset Information

First clinical experience with fractionated intracavitary radioimmunotherapy using [¹⁷⁷Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study.

Background

Methods

Results

Conclusions

Publications

First clinical experience with fractionated intracavitary radioimmunotherapy using [<sup>177</sup>Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

First clinical experience with fractionated intracavitary radioimmunotherapy using [177Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study.

Background

Methods

Results

Conclusions

Publications

First clinical experience with fractionated intracavitary radioimmunotherapy using [<sup>177</sup>Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

First clinical experience with fractionated intracavitary radioimmunotherapy using [¹⁷⁷Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study.