A multi-targeted computational drug discovery approach for repurposing tetracyclines against monkeypox virus.

ABSTRACT: Monkeypox viral infection is an emerging threat and a major concern for the human population. The lack of drug molecules to treat this disease may worsen the problem. Identifying potential drug targets can significantly improve the process of developing potent drug molecules for treating monkeypox. The proteins responsible for viral replication are attractive drug targets. Identifying potential inhibitors from known drug molecules that target these proteins can be key to finding a cure for monkeypox. In this work, two viral proteins, DNA-dependent RNA polymerase (DdRp) and viral core cysteine proteinase, were considered as potential drug targets. Sixteen antibiotic drugs from the tetracycline class were screened against both viral proteins through high-throughput virtual screening. These t

SUBMITTER: Alandijany TA 

PROVIDER: S-EPMC10477205 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature