The voltage-gated sodium channel, para, limits Anopheles coluzzii vector competence in a microbiota dependent manner.

ABSTRACT: The voltage-gated sodium channel, para, is a target of DDT and pyrethroid class insecticides. Single nucleotide mutations in para, called knockdown resistant or kdr, which contribute to resistance against DDT and pyrethroid insecticides, have been correlated with increased susceptibility of Anopheles to the human malaria parasite Plasmodium falciparum. However, a direct role of para activity on Plasmodium infection has not yet been established. Here, using RNA-mediated silencing, we provide in vivo direct evidence for the requirement of wild-type (wt) para function for insecticide activity of deltamethrin. Depletion of wt para, which is susceptible to insecticide, causes deltamethrin tolerance, indicating that insecticide-resistant kdr alleles are likely phenocopies of loss of para functio

SUBMITTER: Nardini L 

PROVIDER: S-EPMC10477260 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature