Immunological characterization and diagnostic models of RNA N6-methyladenosine regulators in Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is the most prevalent form of dementia, and it displays both clinical and molecular variability. RNA N6-methyladenosine (m6A) regulators are involved in a wide range of essential cellular processes. In this study, we aimed to identify molecular signatures associated with m6A in Alzheimer's disease and use those signatures to develop a predictive model. We examined the expression patterns of m6A regulators and immune features in Alzheimer's disease using the GSE33000 dataset. We examined the immune cell infiltration and molecular groups based on m6A-related genes in 310 Alzheimer's disease samples. The WGCNA algorithm was utilized to determine differently expressed genes within each cluster. After evaluating the strengths and weaknesses of the random forest model, t

SUBMITTER: Hui Y 

PROVIDER: S-EPMC10477294 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature