Impact of dietary interventions on pre-diabetic oral and gut microbiome, metabolites and cytokines.

ABSTRACT: Diabetes and associated comorbidities are a global health threat on the rise. We conducted a six-month dietary intervention in pre-diabetic individuals (NCT03222791), to mitigate the hyperglycemia and enhance metabolic health. The current work explores early diabetes markers in the 200 individuals who completed the trial. We find 166 of 2,803 measured features, including oral and gut microbial species and pathways, serum metabolites and cytokines, show significant change in response to a personalized postprandial glucose-targeting diet or the standard of care Mediterranean diet. These changes include established markers of hyperglycemia as well as novel features that can now be investigated as potential therapeutic targets. Our results indicate the microbiome mediates the effect of diet on

SUBMITTER: Shoer S 

PROVIDER: S-EPMC10477304 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature