Sleep duration and age-related macular degeneration: a cross-sectional and Mendelian randomization study

ABSTRACT:

Purpose

To investigate the association between sleep duration and age-related macular degeneration (AMD).

Design

Cross-sectional study, bidirectional two-sample Mendelian randomization (MR). For cross-sectional analysis, we used survey data of 5,481 participants aged ≥40 years from the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES). For MR analysis, we used sleep- and AMD-associated genome-wide association studies (GWAS) data involving large populations.

Methods

The association between sleep duration and AMD was assessed using logistic regression models. For MR analysis, the primary approach for MR analysis was the inverse-variance weighted (IVW) method.

Results

In cross-sectional analysis, after adjusting for multiple covariates,

SUBMITTER: Lei S 

PROVIDER: S-EPMC10477604 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature