Nitric oxide: an old drug but with new horizons in ophthalmology—a narrative review

ABSTRACT:

Background and Objective

Based on basic knowledge and prior research on nitric oxide (NO), the potential of NO for treating eye diseases is reviewed, and the possibility of NO-based eye drops in clinical practice and the future potential of NO in ophthalmology are discussed.

Methods

A PubMed search was performed for English-language original reports and reviews using the following key words: nitric oxide, eye, ocular, and drug.

Key Content and Findings

NO is synthesized in the human body by NO synthase (NOS) from L-arginine or through enzyme-dependent reduction of dietary nitrate. Three types of NOS (eNOS, nNOS, and iNOS) are abundantly expressed in the eye under normal physiologic or pathologic conditions. The biological effect of NO in the eye is dose dependent

SUBMITTER:  

PROVIDER: S-EPMC10477639 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature