Blueprint to hepatitis B elimination in China: A modelling analysis of clinical strategies.

ABSTRACT:

Background & aims

Globally, one-third of individuals infected with HBV live in China. Eliminating HBV in China would therefore be paramount in achieving the World Health Organization's (WHO's) targets of viral hepatitis elimination as a worldwide public health threat.

Methods

We constructed a dynamic HBV transmission model in China, structured by age and sex. We calibrated the model by HBsAg prevalence, acute HBV incidence, and nationally reported HBV-related cancer mortality. We investigated seven intervention scenarios (A-G) based on assumptions in diagnostic, linkage-to-care, and treatment coverages in achieving the WHO's HBV elimination goals.

Results

With the status quo, HBsAg prevalence among children 1-4 years would reduce to 0.09% (95% CI 0.09-0.10%) by

SUBMITTER: Li R 

PROVIDER: S-EPMC10477682 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature