Fibrosis-4 index is associated with the risk of hepatocellular carcinoma in patients with cirrhosis and nonalcoholic steatohepatitis.

ABSTRACT:

Background and aims

Identification of high-risk patients for hepatocellular carcinoma (HCC) is essential for long term monitoring of nonalcoholic steatohepatitis (NASH) cirrhosis progression. We sought to evaluate the association between Fibrosis-4 (FIB-4) index and incidence of HCC risk among patients with NASH cirrhosis.

Methods

We conducted a retrospective cohort study of adult patients with NASH cirrhosis (n= 1,338) who were evaluated in a single medical center between 2005 and 2015. Those who developed HCC were identified through electronic medical records using International Classification of Diseases (ICD) 9 and 10 codes until the end of September 2021.

Results

During a median follow-up time of 3.7 years, 157 (11.7%) patients with NASH cirrhosis developed HCC.

SUBMITTER: Albhaisi S 

PROVIDER: S-EPMC10477779 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature