Magnetically Actuated Biodegradable Nanorobots for Active Immunotherapy.

ABSTRACT: An efficient and cost-effective therapeutic vaccine is highly desirable for the prevention and treatment of cancer, which helps to strengthen the immune system and activate the T cell immune response. However, initiating such an adaptive immune response efficiently remains challenging, especially the deficient antigen presentation by dendritic cells (DCs) in the immunosuppressive tumor microenvironment. Herein, an efficient and dynamic antigen delivery system based on the magnetically actuated OVA-CaCO₃ -SPIO robots (OCS-robots) is rationally designed for active immunotherapy. Taking advantage of the unique dynamic features, the developed OCS-robots achieve controllable motion capability under the rotating magnetic field. Specifically, with the active motion, the acid-responsive

SUBMITTER: Ye Y 

PROVIDER: S-EPMC10477856 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature