Male-Biased Gut Microbiome and Metabolites Aggravate Colorectal Cancer Development.

ABSTRACT: Men demonstrate higher incidence and mortality rates of colorectal cancer (CRC) than women. This study aims to explain the potential causes of such sexual dimorphism in CRC from the perspective of sex-biased gut microbiota and metabolites. The results show that sexual dimorphism in colorectal tumorigenesis is observed in both Apc^{Min/ +} mice and azoxymethane (AOM)/dextran sulfate sodium (DSS)-treated mice with male mice have significantly larger and more tumors, accompanied by more impaired gut barrier function. Moreover, pseudo-germ mice receiving fecal samples from male mice or patients show more severe intestinal barrier damage and higher level of inflammation. A significant change in gut microbiota composition is found with increased pathogenic bacteria Akkermansia

SUBMITTER: Wang L 

PROVIDER: S-EPMC10477899 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature