Insights from Mendelian randomization and genetic correlation analyses into the relationship between endometriosis and its comorbidities.

ABSTRACT:

Background

Endometriosis remains a poorly understood disease, despite its high prevalence and debilitating symptoms. The overlap in symptoms and the increased risk of multiple other traits in women with endometriosis is becoming increasingly apparent through epidemiological data. Genetic studies offer a method of investigating these comorbid relationships through the assessment of causal relationships with Mendelian randomization (MR), as well as identification of shared genetic variants and genes involved across traits. This has the capacity to identify risk factors for endometriosis as well as provide insight into the aetiology of disease.

Objective and rationale

We aim to review the current literature assessing the relationship between endometriosis and other traits using

SUBMITTER: McGrath IM 

PROVIDER: S-EPMC10477944 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature