Ontology highlight
ABSTRACT:
SUBMITTER: Schink SJ
PROVIDER: S-EPMC10477958 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Schink Severin J SJ Gough Zara Z Biselli Elena E Huiman Mariel Garcia MG Chang Yu-Fang YF Basan Markus M Gerland Ulrich U
Cell reports 20220801 9
Adaptive stress resistance in microbes is mostly attributed to the expression of stress response genes, including heat-shock proteins. Here, we report a response of E. coli to heat stress caused by degradation of an enzyme in the methionine biosynthesis pathway (MetA). While MetA degradation can inhibit growth, which by itself is detrimental for fitness, we show that it directly benefits survival at temperatures exceeding 50°C, increasing survival chances by more than 1,000-fold. Using both expe ...[more]