Innate Lymphoid Cells and Interferons Limit Neurologic and Articular Complications of Brucellosis.

ABSTRACT: Brucellosis is a globally significant zoonotic disease. Human patients with brucellosis develop recurrent fever and focal complications, including arthritis and neurobrucellosis. The current study investigated the role of innate lymphoid cells (ILCs) in the pathogenesis of focal brucellosis caused by Brucella melitensis. After footpad infection, natural killer cells and ILC1 cells both limited joint colonization by Brucella. Mice lacking natural killer cells, and in particular mice lacking all ILCs, also developed marked arthritis after footpad infection. Following pulmonary infection, mice lacking adaptive immune cells and ILCs developed arthritis, neurologic complications, and meningitis. Adaptive immune cells and ILCs both limited colonization of the brain by Brucella following pulmonar

SUBMITTER: Moley CR 

PROVIDER: S-EPMC10477959 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature