The aging kidney is characterized by tubuloinflammaging, a phenotype associated with MHC-II gene expression.

ABSTRACT:

Introduction

Even during physiologic aging, the kidney experiences a loss of mass and a progressive functional decline. This is clinically relevant as it leads to an increased risk of acute and chronic kidney disease. The kidney tubular system plays an important role in the underlying aging process, but the involved cellular mechanisms remain largely elusive.

Methods

Kidneys of 3-, 12- and 24-month-old male C57BL/6J mice were used for RNA sequencing, histological examination, immunostaining and RNA-in-situ-hybridization. Single cell RNA sequencing data of differentially aged murine and human kidneys was analyzed to identify age-dependent expression patterns in tubular epithelial cells. Senescent and non-senescent primary tubular epithelial cells from mouse kidney were used f

SUBMITTER: Sinning J 

PROVIDER: S-EPMC10477980 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature