Intracranial meningiomas: an update of the 2021 World Health Organization classifications and review of management with a focus on radiation therapy

ABSTRACT: Meningiomas account for approximately one third of all primary intracranial tumors. Arising from the cells of the arachnoid mater, these neoplasms are found along meningeal surfaces within the calvarium and spinal canal. Many are discovered incidentally, and most are idiopathic, although risk factors associated with meningioma development include age, sex, prior radiation exposure, and familial genetic diseases. The World Health Organization grading system is based on histologic criteria, and are as follows: grade 1 meningiomas, a benign subtype; grade 2 meningiomas, which are of intermediately aggressive behavior and usually manifest histologic atypia; and grade 3, which demonstrate aggressive malignant behavior. Management is heavily dependent on tumor location, grade, and symptomatology

SUBMITTER: Yarabarla V 

PROVIDER: S-EPMC10477988 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature