Effects of endoplasmic reticulum stress on erectile function in rats with cavernous nerve injury

ABSTRACT: Abstract

Background

Erectile dysfunction (ED) occurs in an increasing number of patients after radical prostatectomy and cystectomy, and the phenotypic modulation of corpus cavernosum smooth muscle cells is closely related to ED.

Aim

To determine whether endoplasmic reticulum stress (ERS) is implicated in the phenotypic modulation of ED induced by bilateral cavernous nerve injury (BCNI).

Methods

In total, 36 Sprague-Dawley rats were randomly divided into 3 groups: sham, in which rats received sham surgery with bilateral cavernous nerve exposure plus phosphate-buffered saline; control, in which rats received BCNI plus phosphate-buffered saline; and experimental, in which rats received BCNI plus 4-phenylbutyric acid. Analysis of variance and a Bonferroni multiple-c

SUBMITTER:  

PROVIDER: S-EPMC10478027 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature