Domestic dog lineages reveal genetic drivers of behavioral diversification.

ABSTRACT: Selective breeding of domestic dogs has generated diverse breeds often optimized for performing specialized tasks. Despite the heritability of breed-typical behavioral traits, identification of causal loci has proven challenging due to the complexity of canine population structure. We overcome longstanding difficulties in identifying genetic drivers of canine behavior by developing a framework for understanding relationships between breeds and the behaviors that define them, utilizing genetic data for over 4,000 domestic, semi-feral, and wild canids and behavioral survey data for over 46,000 dogs. We identify ten major canine genetic lineages and their behavioral correlates and show that breed diversification is predominantly driven by non-coding regulatory variation. We determine that lin

SUBMITTER: Dutrow EV 

PROVIDER: S-EPMC10478034 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature