BAFF system expression in double negative 2, activated naive and activated memory B cells in systemic lupus erythematosus.

ABSTRACT:

Introduction

B cell activating factor (BAFF) has an important role in normal B cell development. The aberrant expression of BAFF is related with the autoimmune diseases development like Systemic Lupus Erythematosus (SLE) for promoting self-reactive B cells survival. BAFF functions are exerted through its receptors BAFF-R (BR3), transmembrane activator calcium modulator and cyclophilin ligand interactor (TACI) and B cell maturation antigen (BCMA) that are reported to have differential expression on B cells in SLE. Recently, atypical B cells that express CD11c have been associated with SLE because they are prone to develop into antibody-secreting cells, however the relationship with BAFF remains unclear. This study aims to analyze the BAFF system expression on CXCR5^- CD11c

SUBMITTER: Alvarez Gomez JA 

PROVIDER: S-EPMC10478082 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature