Duration of constant rate infusion with diazepam or propofol for canine cluster seizures and status epilepticus

ABSTRACT:

Introduction

Constant rate infusion (CRI) of benzodiazepines or propofol (PPF) is a therapeutic option for cluster seizures (CS) and status epilepticus (SE) in canine patients non-responding to first-line benzodiazepines or non-anesthetics. However, specific indications for optimal duration of CRI are lacking. The aim of this study was to determine the effect of duration of anesthetic CRI on outcome and length of hospital stay in dogs with refractory seizure activity of different etiology.

Study design

Open-label non-randomized clinical trial.

Materials and methods

Seventy-three client-owned dogs were enrolled. Two groups [experimental (EXP) vs. control (CTRL)] were compared. The EXP group received diazepam (DZP) or PPF CRI for 12 h (±1 h) and the CTRL group rece

SUBMITTER: Cagnotti G 

PROVIDER: S-EPMC10478093 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature