Identification and assessment of differentially expressed necroptosis long non-coding RNAs associated with periodontitis in human.

ABSTRACT:

Background

Periodontitis is the most common oral disease and is closely related to immune infiltration in the periodontal microenvironment and its poor prognosis is related to the complex immune response. The progression of periodontitis is closely related to necroptosis, but there is still no systematic study of long non-coding RNA (lncRNA) associated with necroptosis for diagnosis and treatment of periodontitis.

Material and methods

Transcriptome data and clinical data of periodontitis and healthy populations were obtained from the Gene Expression Omnibus (GEO) database, and necroptosis-related genes were obtained from previously published literature. FactoMineR package in R was used to perform principal component analysis (PCA) for obtaining the necroptosis-related lncRNA

SUBMITTER: He J 

PROVIDER: S-EPMC10478209 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature