Total network controllability analysis discovers explainable drugs for Covid-19 treatment

ABSTRACT:

Background

The active pursuit of network medicine for drug repurposing, particularly for combating Covid-19, has stimulated interest in the concept of structural controllability in cellular networks. We sought to extend this theory, focusing on the defense rather than control of the cell against viral infections. Accordingly, we extended structural controllability to total structural controllability and introduced the concept of control hubs. Perturbing any control hub may render the cell uncontrollable by exogenous stimuli like viral infections, so control hubs are ideal drug targets.

Results

We developed an efficient algorithm to identify all control hubs, applying it to a largest homogeneous network of human protein interactions, including interactions between human an

SUBMITTER: Wei X 

PROVIDER: S-EPMC10478273 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature