Integrated analysis of the ubiquitination mechanism reveals the specific signatures of tissue and cancer.

ABSTRACT:

Background

Ubiquitination controls almost all cellular processes. The dysregulation of ubiquitination signals is closely associated with the initiation and progression of multiple diseases. However, there is little comprehensive research on the interaction and potential function of ubiquitination regulators (UBRs) in spermatogenesis and cancer.

Methods

We systematically characterized the mRNA and protein expression of UBRs across tissues and further evaluated their roles in testicular development and spermatogenesis. Subsequently, we explored the genetic alterations, expression perturbations, cancer hallmark-related pathways, and clinical relevance of UBRs in pan-cancer.

Results

This work reveals heterogeneity in the expression patterns of UBRs across tissues, and the

SUBMITTER: Long D 

PROVIDER: S-EPMC10478310 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature