Micro-inflammation related gene signatures are associated with clinical features and immune status of fibromyalgia

ABSTRACT:

Background

Fibromyalgia (FM) is a multifaceted disease. Along with the genetic, environmental and neuro-hormonal factors, inflammation has been assumed to have role in the pathogenesis of FM. The aim of the present study was to explore the differences in clinical features and pathophysiology of FM patients under different inflammatory status.

Methods

The peripheral blood gene expression profile of FM patients in the Gene Expression Omnibus database was downloaded. Differentially expressed inflammatory genes were identified, and two molecular subtypes were constructed according to these genes used unsupervised clustering analysis. The clinical characteristics, immune features and pathways activities were compared further between the two subtypes. Then machine learning was

SUBMITTER: Yao M 

PROVIDER: S-EPMC10478377 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature