SARS-CoV-2 vaccine breakthrough infection in the older adults: a meta-analysis and systematic review.

ABSTRACT:

Background

Corona Virus Disease 2019 (COVID-19) mRNA vaccine effectiveness (VE) has recently declined, and reports about COVID-19 breakthrough infection have increased. We aimed to conduct a meta-analysis on population-based studies of the prevalence and incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection amongst older adults worldwide.

Methods

Studies from PubMed, Embase, Cochrane Library, and Web of Science were systematically screened to determine the prevalence and incidence of SARS-CoV-2 breakthrough infection in older adults from inception to November 2, 2022. Our meta-analysis included 30 studies, all published in English. Pooled estimates were calculated using a random-effect model through the inverse variance method. Publ

SUBMITTER: Jing X 

PROVIDER: S-EPMC10478381 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature