Metal-organic framework materials promote neural differentiation of dental pulp stem cells in spinal cord injury.

ABSTRACT: Spinal cord injury (SCI) is accompanied by loss of Zn²⁺, which is an important cause of glutamate excitotoxicity and death of local neurons as well as transplanted stem cells. Dental pulp stem cells (DPSCs) have the potential for neural differentiation and play an immunomodulatory role in the microenvironment, making them an ideal cell source for the repair of central nerve injury, including SCI. The zeolitic imidazolate framework 8 (ZIF-8) is usually used as a drug and gene delivery carrier, which can release Zn²⁺ sustainedly in acidic environment. However, the roles of ZIF-8 on neural differentiation of DPSCs and the effect of combined treatment on SCI have not been explored. ZIF-8-introduced DPSCs were loaded into gelatin methacryloyl (GelMA) hydrogel and in situ i

SUBMITTER: Zhou H 

PROVIDER: S-EPMC10478386 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature