Causal associations between thyroid cancer and IgA nephropathy: a Mendelian randomization study.

ABSTRACT:

Background

The incidence of kidney disease caused by thyroid cancer is rising worldwide. Observational studies cannot recognize whether thyroid cancer is independently associated with kidney disease. We performed the Mendelian randomization (MR) approach to genetically investigate the causality of thyroid cancer on immunoglobulin A nephropathy (IgAN).

Methods and results

We explored the causal effect of thyroid cancer on IgAN by MR analysis. Fifty-two genetic loci and single nucleotide polymorphisms were related to thyroid cancer. The primary approach in this MR analysis was the inverse variance weighted (IVW) method, and MR‒Egger was the secondary method. Weighted mode and penalized weighted median were used to analyze the sensitivity. In this study, the random-effect IVW m

SUBMITTER: Mei Z 

PROVIDER: S-EPMC10478414 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature