Sex differences in muscle protein expression and DNA methylation in response to exercise training.

ABSTRACT:

Background

Exercise training elicits changes in muscle physiology, epigenomics, transcriptomics, and proteomics, with males and females exhibiting differing physiological responses to exercise training. However, the molecular mechanisms contributing to the differing adaptations between the sexes are poorly understood.

Methods

We performed a meta-analysis for sex differences in skeletal muscle DNA methylation following an endurance training intervention (Gene SMART cohort and E-MTAB-11282 cohort). We investigated for sex differences in the skeletal muscle proteome following an endurance training intervention (Gene SMART cohort). Lastly, we investigated whether the methylome and proteome are associated with baseline cardiorespiratory fitness (maximal oxygen consumption; VO

SUBMITTER: Landen S 

PROVIDER: S-EPMC10478435 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature