Exogenous female sex steroid hormones and new-onset asthma in women: a matched case-control study.

ABSTRACT:

Background

Evidence on the role of exogenous female sex steroid hormones in asthma development in women remains conflicting. We sought to quantify the potential causal role of hormonal contraceptives and menopausal hormone therapy (MHT) in the development of asthma in women.

Methods

We conducted a matched case-control study based on the West Sweden Asthma Study, nested in a representative cohort of 15,003 women aged 16-75 years, with 8-year follow-up (2008-2016). Data were analyzed using Frequentist and Bayesian conditional logistic regression models.

Results

We included 114 cases and 717 controls. In Frequentist analysis, the odds ratio (OR) for new-onset asthma with ever use of hormonal contraceptives was 2.13 (95% confidence interval [CI] 1.03-4.38). Subgroup analy

SUBMITTER: Zhang G 

PROVIDER: S-EPMC10478448 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature