Transcriptome-wide association study identifies new susceptibility genes and pathways for spondyloarthritis.

ABSTRACT:

Background

Spondyloarthritis (SpA) is a group of multifactorial bone diseases influenced by genetic factors, the environment and lifestyle. However, current studies have found a limited number of SpA-related genes, and the genetic and pathogenic mechanisms of SpA are still unclear.

Methods

A tissue-specific transcriptome-wide association study (TWAS) of SpA was performed using GWAS (including 3966 SpA patients and 448,298 controls) summary data and gene expression weights of whole blood and skeletal muscle. The SpA-associated genes identified by TWAS were further compared with the differentially expressed genes (DEGs) identified in the SpA gene expression profile acquired from the Gene Expression Omnibus database (GEO, GSE58667). Finally, functional enrichment and annotation

SUBMITTER: Su X 

PROVIDER: S-EPMC10478464 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature