Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most common malignancies, affected by several genetic loci in the clinical phenotype. This study aimed to determine the association between PTGER4 and PRKAA1 gene polymorphisms and the risk of GC.

Methods

A total of 509 GC patients and 507 age and sex-matched healthy controls were recruited to explore the association between PTGER4 and PRKAA1 genetic polymorphisms and GC susceptibility. Logistic regression analysis was used to study the correlation between these SNPs and GC, with odd ratio (OR) and 95% confidence interval (CI) as indicators. Multifactor dimensionality reduction was utilized to analyze the genetic relationships among SNPs. was conducted to predict gene expression, the impact of SNPs on gene expression, and the sign

SUBMITTER: Yu S 

PROVIDER: S-EPMC10478487 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature